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KMID : 0350519950480010207
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.207 ~ p.215
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Detection of Epidermal Growth Factor Receptor mRNA by In Situ Hybridization in Cataractous Lens Epithelium
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Abstract
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Recent studies have demonstrated that epidermal growth factor9EGF) and epidermal growth factor receptor(EGFR) play an important role for the proliferation and migration of lens epithelial cell. In human, the lens epithelial cell proliferation is
one of
the causes of the cataract.
In this study, we investigated the correlation between the expression of EGFR-mRNA in situ hybridization method and the clinical picture of the cataract.
@ES The results were as followed ;
@EN 1. Nineteen out of fourty six cases(41,3%) were showed the expression of EGFR-mRNA in lens epithelium.
2. No correlation between the age of the lenses and the expression of EGFR-mRNA could be demonstrated.
3. The expression of EGFR-mRNA in lens epithelium correlated significantly(P<0.01) with the clinical stage of the cataract.
4. No correlation between the diabetes mellitus and the expression of EGFR-mRNA could be demonstated.
These results suggest that the EGFR-mRNA suggest that the EGFR-mRNA status in lens epithelium could be important for the development of the cataract.
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KEYWORD
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